Coating and Reinforcement of the Intracranial Aneurysm With Synthetic Resins and Rubbers

Abstract

After producing experimentally in dogs carotid aneurysms which ruptured spontaneously in 8 to 14 days, we searched for an ideal synthetic resin or rubber to protect such aneurysms from rupturing without any impairment of the blood supply to the brain. From the studies with a total of 16 kinds of different agents in 71 dogs, we found that a combination of methyl 2-cyano-acrylate monomer (Eastman 910-Adhesive), polyisocyanate (Desmodur T) and nitromethane solution of nitrile rubber (Hycar No. 1041) proved to be the ideal one for our purpose. This EDH-Adhesive has been used in 3 human cases with intracranial aneurysms without any unpleasant complications. Thus, we believe that EDH-Adhesive may be used as a means of coating intracranial aneurysms not suitable for other methods of treatment or as an additional means used after unsatisfactory resection or clipping of aneurysmal sacs.