Organic Letters · 2012 · 118 citations · 32 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisFluorination ProcessesIsoquinoline ChemistryIsoquinoline Synthesis
A silver-catalyzed intramolecular oxidative aminofluorination of alkynes has been developed by using NFSI as a fluorinating reagent. This reaction represents an efficient method for the synthesis of various 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.
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A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging
Eunsung Lee, Adam S. Kamlet, David C. Powers et al. · Science · 2011 · 413 citations · Full text