The Canadian Journal of Chemical Engineering · 2000 · 139 citations · 36 references
EngineeringBiotechnologyChemical EngineeringBiochemical EngineeringBioprocess EngineeringBioreactor DesignBioreactor HydrodynamicsFluidized Bed ReactorsFluidized-bed BioreactorsGas-liquid ReactorsBackmixingCirculating Fluidized BedsFluidized Bed HydrodynamicsFluidized Beds
Circulating fluidized beds offer superior interfacial contact and reduced backmixing compared to conventional beds, yet liquid‑solid and gas‑liquid‑solid variants have been sparsely studied. This review extends gas‑solid knowledge to liquid‑solid and gas‑liquid‑solid systems, aiming to develop highly efficient reactors for biotechnology. The article surveys recent progress in liquid‑phase circulating fluidized beds to assess their potential. It discusses how these systems can be applied to biochemical processes.
Abstract Compared with conventional fluidized beds, circulating fluidized beds have many advantages including better interfacial contacting and reduced backmixing (Lim et al., 1995). While there are many reports on the gas—solid circulating fluidized systems, liquid—solid and gas—liquid—solid circulating fluidized bed systems have been scantily studied. However, extending current knowledge obtained in gas—solid systems to liquid—solids and gas—liquid—solid three‐phase systems is shown to open new horizons for applications of circulating fluidized bed technology and expected to lead to the development of highly efficient liquid—solid and gas—liquid—solid reactors, especially for the ever growing field of biotechnology. In order to fully appreciate the potential of those two types of liquid phase circulating fluidized beds, recent progress is reviewed in this article. Their potential applications to biochemical processes are also discussed.
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Hydrodynamics of liquid fluidisation
Renzo Di Felice · Chemical Engineering Science · 1995 · 287 citations
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Kelly Lim, Jesse Zhu, John R. Grace · International Journal of Multiphase Flow · 1995 · 270 citations
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