Study to establish the role of JAK2 and SMAD1/5/8 pathways in the inhibition of hepcidin by polysaccharides from Angelica sinensis

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

Laura Silvestri, Alessia Pagani, Antonella Nai et al. · Cell Metabolism · 2008 · 545 citations · Full text

Protein Function, Signal Transduction, Serine Protease Matriptase-2 +12

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

Léon Kautz, Delphine Meynard, Annabelle Monnier et al. · Blood · 2008 · 431 citations · Full text

The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction

Stefan N. Constantinescu, Saghi Ghaffari, Harvey F. Lodish · Trends in Endocrinology and Metabolism · 1999 · 230 citations

Signal Transduction, Receptor (Biochemistry), Heme Signaling +5

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway

Alessia Calzolari, Carla Raggi, Silvia Deaglio et al. · Journal of Cell Science · 2006 · 186 citations

Immunology, Molecular Biology, Extracellular Microvesicles +20

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

Karin E. Finberg, Rebecca L. Whittlesey, Mark D. Fleming et al. · Blood · 2010 · 161 citations · Full text