Palladium‐Catalyzed Amidation and Amination of 8‐Iodopurine

Abstract

Abstract The synthesis of 8‐amido‐ and 8‐aminopurines by a single palladium‐catalyzed protocol is reported. The method proceeds efficiently and tolerates a wide range of amides and amines as coupling partners, including aryl, alkyl, sulfone, and acetal amides, as well as deactivated m ‐ and p ‐nitroanilines. In this way, a library of new 6,8,9‐trisubstituted purines has been synthesized.