Carbonylative coupling of an amino acid-derived organozinc reagent with functionalized aryl iodides: synthesis of kynurenine

Abstract

The utility of the palladium(0) catalysed reaction of the serine-derived organozinc reagent 6 with functionalized aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo α-amino acids 8 is illustrated by a short synthesis of L-kynurenine.