Epigenetic silencing of DACH1 induces loss of transforming growth factor-<i>β</i>1 antiproliferative response in human hepatocellular carcinoma

Abstract

DACH1 is frequently methylated in HCC and DACH1 expression is regulated by promoter hypermethylation. Down-regulation of DACH1 is a novel mechanism for gaining resistance to the antiproliferative signaling of TGF-β1 and 5-FU resistance.