Transcriptional Profile Analysis of<i>RPGR</i>ORF15 Frameshift Mutation Identifies Novel Genes Associated with Retinal Degeneration

Abstract

Several DE genes were identified in mutant retinas. At 7 weeks, a combination of nonclassic anti- and proapoptosis genes appear to be involved in photoreceptor degeneration, whereas at both 7 and 16 weeks, the expression of mitochondria-related genes indicates that they may play a relevant role in the disease process.