Impact on Uterine Bleeding and Endometrial Thickness: Tibolone Compared with Continuous Combined Estradiol and Norethisterone Acetate Replacement Therapy

Abstract

Use of tibolone 2.5 mg daily for 1 year was associated with significantly less bleeding and spotting compared with daily continuous combined 2 mg estradiol and 1 mg norethisterone acetate in postmenopausal women in the presence of both minimal and nonprogressive increase of endometrial thickness associated with the two regimens.