Journal of Biomechanical Engineering · 1980 · 140 citations · 0 references
Life SciencesPhysiologyFluid DynamicsMechanobiologyRheologyHemodynamicsVascular AnatomyVascular PathologyVascular TissueArterial Fluid MechanicsArterial Wall MechanicsArterial Wall ThickeningAtherosclerotic Plaque MechanicsBlood Flow DynamicsBlood Vessel Wall MechanicsVascular MechanicsVascular Tissue Mechanics
A 1978 specialist meeting at Ohio State University reviewed fluid mechanics’ role in atherogenesis, following a 1974 conference. The paper summarizes current knowledge on fluid mechanics’ influence on arterial lesion initiation and progression, and identifies unresolved questions and future research needs. The discussion focuses on lesion localization, hemodynamics in high‑risk arterial segments, and the interaction between flow dynamics and the arterial wall.
A specialists meeting on “The Role of Fluid Mechanics in Atherogenesis” was held August 24–25, 1978, at The Ohio State University. This meeting was a followup to a similar meeting held in 1974 [1, 2]. The present status of our knowledge of the importance of fluid mechanics in the initiation and progression of arterial lesions is summarized on the basis of the experimental data presented at the meeting; no attempt is made to provide a comprehensive review of the relevant literature. Three basic aspects are addressed: firstly, the localization of arterial lesions; secondly, the local hemodynamics of arterial segments with a high predilection to the development of lesions; and thirdly, the interaction of hemodynamic factors with the arterial wall. The many unresolved questions, apparently conflicting experimental data and areas in need of future research on the role of fluid mechanics in atherogenesis are identified specifically.