New methods in peptide synthesis, based on supernucleophiles

Abstract

The fragmentation of S-halogenated alkyl groups and 5-halogenated butenyl groups from the N-and C-termini of a-amino acids and peptide derivatives by the supernucleophilic Coi-phthalocyanine anion as well as related reactions are presented as the basis of some new protecting group techniques and synthetic methods for peptides.