Extensive extramedullary disease in myeloma: An uncommon variant with features of poor prognosis and dedifferentiation

Abstract

The simultaneous appearance of plasmacytomas in multiple extramedullary sites heralds a change of clinical behavior in myeloma. When accompanied by the disappearance of serum myeloma protein, and marrow plasma cell infiltration, and serum LDH elevation, the disorder may follow a fulminant course.