Science · 2009 · 941 citations · 15 references
Life SciencesBiologyEntomologyHost-pathogen InteractionsInsect EcologyInsect GeneticsDisease Transmission In InsectsInsect PathogensMosquito BiologyMosquito-borne DiseasesVector-host InteractionsVector-pathogen InteractionsAedes Aegypti TransmissionDengue Vector ControlLife Span ExtensionMosquito LongevityMosquito Vector EcologySymbiont InheritanceVector-borne Pathogen DynamicsVector-pathogen Coevolution
Pathogens require a long development period in mosquitoes, making only older insects epidemiologically relevant. The life‑shortening Wolbachia strain was successfully introduced into Aedes aegypti, halving adult lifespan, stably inherited maternally, inducing complete cytoplasmic incompatibility, and indicating that targeting mosquito age with Wolbachia could reduce dengue transmission.
Most pathogens require a relatively long period of development in their mosquito vector before they can be transmitted to a new human host; hence, only older insects are of epidemiological importance. The successful transfer of a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions. The association is stable, and the Wolbachia strain is maternally inherited at high frequency. It is capable of inducing complete cytoplasmic incompatibility, which should facilitate its invasion into natural field populations and its persistence over time. Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses.
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