Synthesis, Physical and Biological Properties of the Phosphorus Analogues Of Phenylalanine and Related Compounds

Abstract

Abstract The study of phosphorus analogues of the natural a-amino acids has accelerated in the past fifteen years, not least due to the finding of molecules with useful biological activity. Our knowledge in this area has been summarized in several recent review articles1-5 Furthermore aminophosphonic acids find increasing use as a tool in investigating the metabolism of natural amino acids.6 The family of 1-aminoalkylphosphonic acids has been most studied and to date analogues of all the common protein amino acids have been described in the literature.