Concepedia

Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist

Tetsuya Masada, Ya Hua, Guohua Xi, Guo‐Yuan Yang, Julian T. Hoff, Richard F. Keep

Journal of neurosurgery · 2001 · 96 citations · 43 references

DOI

Abstract

Overexpression of IL-1ra by using an adenovirus vector attenuated brain edema formation and thrombin-induced intracerebral inflammation following ICH. The reduction in ICH-induced edema with IL-1ra may result from reduction of thrombin-induced brain inflammation.

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