BMJ · 1983 · 37 citations · 9 references
MedicineOncologyCancer ScreeningEarly DetectionGastroenterologyCancer DetectionColonic DiseasesColorectal CancerDigital Rectal ExaminationFalse PositivesScreeningAnorectal ExaminationColonoscopy ScreeningColorectal Cancer DiagnosisColorectal Cancer ScreeningColorectal Screening False PositivesDigital Rectal Examination SensitivityFalse-positive ResultsScreening Test Validity
Hemoccult faecal occult blood testing is widely advocated as a screening test for colorectal cancer but few studies have shown its correlation with conventional methods of investigation for colorectal disease. In a prospective study of 802 symptomatic patients with suspected colorectal disease there was good patient compliance (92.5%) and a high specificity for colorectal cancer (85.4%). The false positive rate was 8.6% (12 of 140 patients with positive results), and while the test result was positive in 22 of 26 colonic cancers the false negative rate for rectal cancer (45.4%) should not detract from its value as a screening test if proper digital anorectal and proctosigmoidoscopic examination are widely practised. A positive Hemoccult test result is a useful indicator for the need to proceed to full colorectal investigation, including colonoscopy.
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Occult blood testing for detection of asymptomatic colon cancer
David H. Greegor · Cancer · 1971 · 205 citations · Full text
Colonoscopy for unexplained rectal bleeding.
E.T. Swarbrick, D. I. Fevre, Richard H. Hunt et al. · BMJ · 1978 · 68 citations · Full text
Screening for colorectal cancer: An overview
Sidney J. Winawer · Cancer · 1980 · 54 citations · Full text
Outcome in colorectal carcinoma: seven-year study of a population.
D N Clarke, P F Jones, C. D. Needham · BMJ · 1980 · 53 citations · Full text