Nerve growth factor‐induced substance P in capsaicin‐insensitive vagal neurons innervating the lower mouse airway

Abstract

Based on the extent of SP and trkA co-expression in airway-specific neurons by NGF treatment, the present study suggests that, following a peripheral activation of trkA receptor on SP afferent by NGF which is elevated in allergic inflammation, there may be trkA-mediated SP induction to mediate neurogenic airway inflammation.