Fat Mobilization in Man

Abstract

Review1 August 1961Fat Mobilization in ManMORTON D. BOGDONOFF, M.D., E. HARVEY ESTES JR., M.D., SAMUEL J. FRIEDBERG, M.D., ROBERT F. KLEIN, M.D.MORTON D. BOGDONOFF, M.D.Search for more papers by this author, E. HARVEY ESTES JR., M.D.Search for more papers by this author, SAMUEL J. FRIEDBERG, M.D.Search for more papers by this author, ROBERT F. KLEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe process of fat mobilization has become accessible to study in man with the recognition that the albumin-bound nonesterified or free fatty acids are the major form of transport of lipid moving from the adipose tissue depots to the sites of lipid utilization elsewhere. Previously, information concerning fat mobilization was derived primarily from animal studies. The animal studies have been extensively reviewed elsewhere (1) and will be mentioned only when human studies have only incompletely settled specific issues. During the past five years a number of observations have been made in man which now merit review and which permit the...References1. LEVINFARBER LRK: Hormonal factors which regulate the mobilization of depot fat to the liver. Recent Prog. in Hormone Research 7: 399, 1952. Google Scholar2. DOLE VP: A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J. Clin. Invest. 35: 150, 1956. CrossrefMedlineGoogle Scholar3. GORDONCHERKES RSA: Unesterified fatty acid in human blood plasma. J. Clin. Invest. 35: 206, 1956. CrossrefMedlineGoogle Scholar4. FREDRICKSONGORDON DSRS: The metabolism of albumin-bound C14-labeled unesterified fatty acids in normal human subjects. J. Clin. Invest. 37: 1504, 1958. CrossrefMedlineGoogle Scholar5. BALLARDDANFORTHNAEGLEBING FBWHSRJ: Myocardial metabolism of fatty acids. J. 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GOODMAN DS: The interaction of human serum albumin with long-chain fatty acid anions. J. Amer. Chem. Soc. 80: 3892, 1958. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North CarolinaReceived for publication February 24, 1961.From the Department of Medicine, Duke University Medical Center, and the Durham Veterans Administration Hospital, Durham, N. C.Supported in part by the Duke University Center for the Study of Aging (grants H-3582 and M-2109), the Irwin Strasburger Memorial Fund, and the Life Insurance Medical Research Fund.Requests for reprints should be addressed to Morton D. Bogdonoff, M.D., Department of Medicine, Duke University Medical Center, Durham, N. C. 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