Increased formation of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

Keith C. Cheng, D S Cahill, Hiroshi Kasai et al. · Journal of Biological Chemistry · 1992 · 1.8K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators

Ercole L. Cavalieri, Douglas E. Stack, Prabhakar D. Devanesan et al. · Proceedings of the National Academy of Sciences · 1997 · 730 citations

Medicine, Molecular Biology, Oncology +17

Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk

David Ryberg · Carcinogenesis · 1997 · 422 citations · Full text

Medicine, Genetics, Oncology +17

Role of oxidative DNA damage in cancer initiation and promotion.

Henrik E. Poulsen, Helene Priemé, Steffen Loft · PubMed · 1998 · 346 citations

Medicine, Molecular Biology, Oncology +17

Association Between Glutathione S-Transferase M1, P1, and T1 Genetic Polymorphisms and Development of Breast Cancer

Kathy J. Helzlsouer, Han‐Yao Huang, Sandra C. Hoffman et al. · JNCI Journal of the National Cancer Institute · 1998 · 293 citations · Full text

Life Sciences, Genetics, Oncology +16