Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

Joseph A. DiDonato, Makio Hayakawa, David M. Rothwarf et al. · Nature · 1997 · 2.1K citations · Full text

Inflammation, Cytokine, Transcriptional Regulation +11

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Frank Mercurio, Hengyi Zhu, Brion W. Murray et al. · Science · 1997 · 2K citations

Immunology, Molecular Biology, Inflammation +20

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

Ebrahim Zandi, David M. Rothwarf, Mireille Delhase et al. · Cell · 1997 · 1.8K citations · Full text

Transcriptional Regulation, Molecular Physiology, Signal Transduction +15

Activities at the Universal Protein Resource (UniProt)

Nucleic Acids Research · 2013 · 1.8K citations · Full text

Protein Assembly, Genetics, Molecular Biology +21

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

Shoji Yamaoka, Gilles Courtois, Christine Bessia et al. · Cell · 1998 · 1.1K citations · Full text

Transcriptional Regulation, Molecular Physiology, Signal Transduction +12