Genotype-phenotype Analysis in Childhood-onset Crohnʼs Disease: NOD2/CARD15 Variants Consistently Predict Phenotypic Characteristics of Severe Disease

Abstract

These NOD2/CARD 15 variants in the Scottish early onset CD population have a definite, albeit relatively small contribution to CD susceptibility (PAR 7.9%) but a major impact on phenotype. In particular NOD2/CARD15 variants are strongly associated with several markers of disease severity in pediatric CD, notably need for surgery.