Rosiglitazone Regulates ENaC and Na-K-2Cl Cotransporter (NKCC<sub>2</sub>) Abundance in the Obese Zucker Rat

Abstract

Chronic RGZ treatment of obese Zucker rats may preserve renal sodium reabsorptive capacity by its indirect actions to attenuate hyperglycemia as well as direct effects on transporter abundance and activity.