Synthetic Communications · 1995 · 13 citations · 4 references
EngineeringOrganic ChemistryChemistryHeterocycle ChemistryChemical DerivativeConvenient SynthesisStereoselective SynthesisVarious 1-Substituted-3-methylisoquinoline-4-carbonitrilesDerivativesBiochemistryDiversity-oriented SynthesisPharmacologyNatural Product SynthesisEnantioselective SynthesisBiomolecular EngineeringNatural SciencesIsocoumarin DerivativeDerivative (Chemistry)Hydrogen Nucleophiles
Abstract The product from the diacetylation of α-cyano-o-tolunitrile has now been assigned as an isocoumarin derivative. This is readily transformed into various 1-substituted-3-methylisoquinoline-4-carbonitriles by reaction with oxygen, nitrogen, carbon and hydrogen nucleophiles.
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