Organic Letters · 2011 · 100 citations · 44 references
Natural SciencesChemical EngineeringChemistryCatalysisReaction EngineeringCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic MaterialsCatalytic MechanismsAsymmetric CatalysisAsymmetric Catalyst DesignAsymmetric SynthesisChiral Catalyst DesignChiral Product SynthesisEnantioselective Catalyst DesignEnantioselective SynthesisMagnesium Catalysis
Conditions for a catalytic asymmetric aza-Darzens aziridine synthesis mediated by a vaulted biphenanthrol (VAPOL) magnesium phosphate salt is described. Using simple substrates, this methodology explores the scope and reactivity of a new magnesium catalyst for an aziridination reaction capable of building chirality and complexity simultaneously.
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