Concepedia

Polychlorinated Biphenyls Disrupt Intestinal Integrity via NADPH Oxidase-Induced Alterations of Tight Junction Protein Expression

Yean Jung Choi, Melissa J. Seelbach, Hong Pu, Sung Yong Eum, Lei Chen, Bei Zhang, Bernhard Hennig, Michał Toborek

Environmental Health Perspectives · 2010 · 88 citations · 26 references

DOIFull text

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Abstract

These results suggest that oral exposure to highly chlorinated PCBs disrupts intestinal epithelial integrity and may directly contribute to the systemic effects of these toxicants.

References

26

Human gut microbes associated with obesity

Ruth E. Ley, Peter J. Turnbaugh, Samuel Klein et al. · Nature · 2006 · 8.6K citations

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PCB problems in the future: Foresight from current knowledge

Shinsuke Tanabe · Environmental Pollution · 1988 · 518 citations

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Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood–brain barrier dysfunction

James Haorah, Servio H. Ramirez, Kathy Schall et al. · Journal of Neurochemistry · 2006 · 328 citations · Full text

Occludin Phosphorylation in Regulation of Epithelial Tight Junctions

Radhakrishna Rao · Annals of the New York Academy of Sciences · 2009 · 216 citations · Full text

The Relationship between Prenatal PCB Exposure and Intelligence (IQ) in 9-Year-Old Children

Paul W. Stewart, Edward Lonky, Jacqueline Reihman et al. · Environmental Health Perspectives · 2008 · 207 citations · Full text