Regulation of the Human Cardiac Mitochondrial Ca ²⁺ Uptake by 2 Different Voltage-Gated Ca ²⁺ Channels

Abstract

Thus, we conclude that the human mitochondrial Ca(2+) uptake is mediated by these 2 distinct Ca(2+) channels, which are functionally impaired in heart failure. Current properties reveal that the mCa1 channel underlies the human MCU and that the mCa2 channel is responsible for the ruthenium red-insensitive/low-sensitivity non-MCU-type mitochondrial Ca(2+) uptake.