Publication | Closed Access
Persistence of the Entire Epstein-Barr Virus Genome Integrated into Human Lymphocyte DNA
154
Citations
24
References
1984
Year
Viral ReplicationGeneticsImmunologyMolecular BiologyHuman Lymphocyte DnaTerminal RepeatMolecular GeneticsCancer-associated VirusViral PersistenceMolecular DiagnosticsVirus GeneViral GeneticsDna ReplicationVirologyCell BiologyVirus-cell Junction SiteChromatinNatural SciencesPathogenesisCell DnaMedicineViral OncologyGenome Editing
The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.
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