Concepedia

Angiopoietin-1 Inhibits Irradiation- and Mannitol-Induced Apoptosis in Endothelial Cells

Hee Jin Kwak, Song Jae Lee, Yeun-Hee Lee, Chul Hee Ryu, Keum Nim Koh, Ha Young Choi, Gou Young Koh

Circulation · 2000 · 92 citations · 27 references

DOIFull text

Open access

Abstract

Ang1 promotes the survival of endothelial cells in irradiation- and mannitol-induced apoptosis through Tie2 receptor binding and PI3-kinase activation. Pretreatment with Ang1 could be beneficial in maintaining normal endothelial cell integrity during intracoronary irradiation or systemic mannitol therapy.

References

27

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Peter C. Maisonpierre, Chitra Suri, Pamela F. Jones et al. · Science · 1997 · 3.5K citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Chitra Suri, Pamela F. Jones, Sybill Patan et al. · Cell · 1996 · 2.8K citations · Full text

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Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

Jocelyn Holash, Peter C. Maisonpierre, Debra Compton et al. · Science · 1999 · 2.2K citations

, , +17

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

Hans-Peter Gerber, Amy E. McMurtrey, Joe Kowalski et al. · Journal of Biological Chemistry · 1998 · 2K citations · Full text

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

Samuel Davis, Thomas H. Aldrich, Pamela F. Jones et al. · Cell · 1996 · 2K citations · Full text

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