Concepedia

Dissection of the mechanism of traditional Chinese medical prescription-Yiqihuoxue formula as an effective anti-fibrotic treatment for systemic sclerosis

Ting Wu, Haiyan Chu, Wenzhen Tu, Mengmeng Song, Dongdong Chen, Jin Yuan, Ling Yu, Yanyun Ma, Qingmei Liu, Jin Li,

BMC Complementary and Alternative Medicine · 2014 · 29 citations · 28 references

DOIFull text

Open access

Abstract

Yiqihuoxue treatment could effectively reduce collagen production via down-regulating the phosphorylation of Smad3 and then the activity of SBE, which are involved in the TGF-β pathway and constitutively activated in the progression of SSc.

References

28

Dissection of mechanisms of Chinese medicinal formula Realgar- <i>Indigo naturalis</i> as an effective treatment for promyelocytic leukemia

Lan Wang, Guang‐Biao Zhou, Ping Liu et al. · Proceedings of the National Academy of Sciences · 2008 · 727 citations · Full text

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Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

Jingsong Zhao, Wei Shi, Yanling Wang et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2002 · 405 citations

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

Shu-Jen Chen, Weihua Yuan, Yasuji Mori et al. · Journal of Investigative Dermatology · 1999 · 401 citations · Full text

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Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

Tamihiro Kawakami, Hironobu Ihn, Weidong Xu et al. · Journal of Investigative Dermatology · 1998 · 252 citations

, , +13

Synergistic Cooperation between Sp1 and Smad3/Smad4 Mediates Transforming Growth Factor β1 Stimulation of α2(I)-Collagen (COL1A2) Transcription

Wen Zhang, Jiongwen Ou, Yutaka Inagaki et al. · Journal of Biological Chemistry · 2000 · 211 citations · Full text