Preparation of Chiral β-Hydroxyketones by Aldol-type Condensation of Chiral<i>p</i>-Tolylsulfinylmethyl Ketones

Abstract

Chiral ß-hydroxyketones 7 with fair e.e. were prepared by treating newly prepared optically pure p-tolylsulfinylmethyl ketones 4 with t-butyl-magnesium bromide and aldehydes 5 followed by desulfurization with aluminium amalgam.