Novel Synthesis of 3-Fluoro-1-Aminoadamantane and Some of its Derivatives

Abstract

Abstract The title compound, 3-fluoro-1-aminoadamantane, isolated as the hydrochloride, has been synthesized in a three-step reaction sequence which is both convenient and rapid. Three derivatives of the amine, 3-fluoro-1-(N-adamantyl)-p-toluenesulfonamide, 3-fluoro-1-(N-adamantyl) benzamide, and 3-fluoro-1-methyl-(N-adamantyl) carbamate, have also been prepared. All compounds were characterized by the usual methods.