Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

Hidetoshi Hayashi, Shirin Abdollah, Yubin Qiu et al. · Cell · 1997 · 1.3K citations · Full text

Life Sciences, Cell Biology, Cell Signaling +7

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

Peter A. Kavsak, Richele K. Rasmussen, Carrie G. Causing et al. · Molecular Cell · 2000 · 1.3K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Podocyte loss and progressive glomerular injury in type II diabetes.

Maria Enrica Pagtalunan, Paul L. Miller, S Jumping-Eagle et al. · Journal of Clinical Investigation · 1997 · 1.1K citations · Full text

Medicine, Nephrology, Pathology +17

Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy

Katalin Suszták, Amanda C. Raff, Mario Schiffer et al. · Diabetes · 2006 · 1.1K citations

Medicine, Nephrology, Physiology +17

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in <i>db/db</i> diabetic mice

Fuad N. Ziyadeh, Brenda B. Hoffman, Dong Cheol Han et al. · Proceedings of the National Academy of Sciences · 2000 · 911 citations · Full text

Medicine, Endocrinology, Nephrology +15