Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide

Activation of a Cytosolic ADP-ribosyltransferase by Nitric Oxide-generating Agents

Bernhard Brüne, E G Lapetina · Journal of Biological Chemistry · 1989 · 363 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function.

Gordon R. Bernard, William D. Lucht, Michael E. Niedermeyer et al. · Journal of Clinical Investigation · 1984 · 303 citations · Full text

Medicine, Pharmacology, Physiology +16

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

Klaus‐Dietrich Kröncke, Victoria Kolb-Bachofen, Britta Berschick et al. · Biochemical and Biophysical Research Communications · 1991 · 257 citations

Life Sciences, Cell Biology, Immunology +13

Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.

Yasuko Uchigata, Hiroshi Yamamoto, Ayata Kawamura et al. · Journal of Biological Chemistry · 1982 · 250 citations · Full text

Life Sciences, Endocrinology, Pharmacology +16

Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice

Kentaro Yamada, Kyohei Nonaka, Toshiaki Hanafusa et al. · Diabetes · 1982 · 221 citations

Medicine, Pharmacology, Clinical Pharmacology +9