Diabetic Nephropathy in Hypertransfused Patients With β-Thalassemia: The role of oxidative stress

Abstract

Early development and an accelerated course of diabetic nephropathy in iron-loaded patients with beta-thalassemia are observed. These findings may be attributed to high oxidative stress in these patients, which is secondary to iron-derived free radicals and to the patients' diminished antioxidant reserves.