Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

Anita Schuchardt, Vivette D. D’Agati, Lena Larsson-Blomberg, +2

Nature

Signal TransductionReceptor Tyrosine KinasePhysiologyMolecular NeurobiologyNervous System +5

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

Zhou Songyang, Kermit L. Carraway, Michael J. Eck, +11

Nature

Signal TransductionEngineeringSignaling PathwayReceptor Tyrosine KinaseProtein Phosphorylation +6

Activation of a novel human transforming gene, ret, by DNA rearrangement

Masahide Takahashi, Jerome Ritz, Geoffrey M. Cooper

Cell

Dna RearrangementReverse GeneticsNatural SciencesGeneticsDna Replication +5

GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

G Cacalano, Isabel Fariñas, Li-Chong Wang, +10

Neuron

Signal TransductionMolecular PhysiologyDevelopmental BiologyG Protein-coupled ReceptorVascular Biology +10

Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.

Rosangela Donghi, Alberto Longoni, S. Pilotti, +3

Journal of Clinical Investigation

Tumor BiologyCancer PathologyMalignant DiseaseP53 GeneGenetics +12

Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis

Esther de Graaff, Shankar Srinivas, Carol Kilkenny, +4

Genes & Development

GeneticsRet IsoformsCellular PhysiologyDifferential ActivitiesEmbryology +16

Molecular Characterization of a Thyroid Tumor-Specific Transforming Sequence Formed by the Fusion of <i>ret</i> Tyrosine Kinase and the Regulatory Subunit RIα of Cyclic AMP-Dependent Protein Kinase A

Italia Bongarzone, Nicoletta Monzini, Maria Grazia Borrello, +6

Molecular and Cellular Biology

GeneticsMolecular BiologyTumor BiologyMolecular CharacterizationPka Gene +14

Cypher, a Striated Muscle-restricted PDZ and LIM Domain-containing Protein, Binds to α-Actinin-2 and Protein Kinase C

Qiang Zhou, Pilar Ruiz‐Lozano, Maryann E. Martone, +1

Journal of Biological Chemistry

Loss of function effect of RET mutations causing Hirschsprung disease

Barbara Pasini, Maria Grazia Borrello, Angela Greco, +12

Nature Genetics

Gene TherapiesRet MutationsGenetic DisorderGeneticsPathology +5

The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ

Maria Grazia Borrello, Luisella Alberti, Elena Arighi, +9

Molecular and Cellular Biology

Molecular BiologyFull Oncogenic ActivityTumor BiologyFunctional PlcgammaSignaling Pathway +16