Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

Further advances in the chemistry of mannich bases

Maurilio Tramontini, Luigi Angiolini · Tetrahedron · 1990 · 414 citations

Organic Chemistry, Main Group Chemistry, Chemistry +2

Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain.

S. Scott Bowersox, T Gadbois, Tejinder Singh et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 275 citations

Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-lll)

Bon H. Verweij, Paul Muizelaar, Federico C. Viñas et al. · Neurological Research · 1997 · 150 citations

Selective N-Type Calcium Channel Antagonist Omega Conotoxin MVIIA Is Neuroprotective Against Hypoxic Neurodegeneration in Organotypic Hippocampal-Slice Cultures

Ashley K. Pringle, Christopher D. Benham, Lulu Sim et al. · Stroke · 1996 · 95 citations

Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats

S. Scott Bowersox, Tejinder Singh, Robert R. Luther · Brain Research · 1997 · 47 citations

Cerebral Vascular Regulation, Selective Blockade, Neurophysiology +13