Concepedia

Endothelial Cell–Specific Deficiency of Ang II Type 1a Receptors Attenuates Ang II–Induced Ascending Aortic Aneurysms in LDL Receptor <sup>−/−</sup> Mice

Debra L. Rateri, Jessica J. Moorleghen, Anju Balakrishnan, A. Phillip Owens, Deborah A. Howatt, Venkateswaran Subramanian, Aruna Poduri, Richard Charnigo, Lisa A. Cassis, Alan Daugherty

Circulation Research · 2011 · 155 citations · 40 references

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Abstract

Ang II infusion promotes aneurysms in the ascending aorta via stimulation of AT(1a) receptors that are expressed on endothelial cells.

References

40

2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease

Circulation · 2010 · 2.3K citations · Full text

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Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Jennifer Habashi, Daniel P. Judge, Tammy M. Holm et al. · Science · 2006 · 1.8K citations · Full text

, , +17

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice

Alan Daugherty, Michael W. Manning, Lisa A. Cassis · Journal of Clinical Investigation · 2000 · 1.4K citations · Full text

Fate of the mammalian cardiac neural crest

Xiaobing Jiang, David H. Rowitch, Philippe Soriano et al. · Development · 2000 · 1.1K citations

Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome

Benjamin S. Brooke, Jennifer Habashi, Daniel P. Judge et al. · New England Journal of Medicine · 2008 · 832 citations · Full text