Sch 36605, structure of a novel nucleoside.

Abstract

A novel nucleoside antibiotic, Sch 36605, has been isolated from the culture filtrate of a Streptomycete sp.;. All the physico-chemical and spectroscopic data presented herein indicate this compoundis a new blasticidin compound. A second closely related component, Sch 36606, was isolated0 together with Sch 36605. This compoundhas been characterized and identified as leucylblasticidin S2). Sch 36605 (1) is a water soluble basic compound: MP >230C (dec); [a]2D6 +58.2(c 0.1, H2O); IR (KBr) cm"1 3300 (br, NH and OH), 1650 (CONH), 1000-1150; UV ^max (H2O, pH 7) nm (e) 272 (8,350); ^max (0.01 n HC1) nm (e) 279 (ll,240).