Concepedia

The Effects of Isoflurane-Induced Electroencephalographic Burst Suppression on Cerebral Blood Flow Velocity and Cerebral Oxygen Extraction During Cardiopulmonary Bypass

Bj rn Reinsfelt, A. Westerlind, Erik Houltz, Sonny Ederberg, Mikael Elam, Sven‐Erik Ricksten

Anesthesia & Analgesia · 2003 · 17 citations · 23 references

DOI

Abstract

The effects of isoflurane on cerebral blood flow velocity (CBFV) and oxygen extraction (COE) as a function of perfusion pressure were studied. When added to fentanyl anesthesia, isoflurane induced a 27% and 13% decrease in CBFV and COE, respectively. CBFV became more pressure-dependent with isoflurane indicating an impaired autoregulation.

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