American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 2005 · 36 citations · 22 references
Life SciencesGeneticsPsychologyBehavioral GeneticsNeurogeneticsPersonality PsychologyDepressive DisordersMoodNeuropsychiatric GeneticsPersonality AssessmentPersonality GeneticsPsychiatric GeneticsCharacter InventoryGenetic Basis Of TraitsGenetic Correlates Of TemperamentMolecular Genetic Basis Of TemperamentSerotonergic Modulation Of MoodSerotonin Receptor PolymorphismsSerotonin Transporter Gene VariantsSerotonin Transporter Polymorphism
Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT(1A)*C/C genotype showed significantly lower scores at the total self-transcendence and at the sub-scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait.
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