An Evaluation of the Possible use of Prostaglandin E₁, E₂ and F_2α for Induction of Labour

Abstract

The stimulatory effect on uterine contractility of prostaglandin E 1 , E 2 and F 2α was studied in 29 term pregnant women and 4 midpregnant volunteers admitted for therapeutic abortion. The substances were administered intravenously and uterine contractility recorded by measuring the amniotic pressure. In a careful analysis of the quantitative tracings it was found that suitable doses of the prostaglandins induce efficient uterine contractions. However, these contractions are characterized by a comparatively low intensity in relation to frequency and also occurrence of incoordinated contraction complexes. The results do not support the opinion that the prostaglandins are superior to oxytocin for induction of labour at term pregnancy.