Archives of Internal Medicine · 1969 · 27 citations · 1 references
MedicineHematologyPharmacotherapyChemotherapyHematologic OncologyMedical OncologyChemotherapy In Hematologic MalignanciesCombination ChemotherapyCytotoxic ChemotherapyHematologic MalignanciesHematologic Malignancy TherapyHematologic ToxicityAcute Leukemia ChemotherapyAcute Myeloid Leukemia TherapyAdult Hematologic Malignancy ChemotherapyBlast CrisisChronic Leukemia ChemotherapyChronic Lymphocytic Leukemia TherapyClinical RemissionMyeloablative Chemotherapy
Thirteen patients with chronic granulocytic leukemia who had entered an accelerating phase ("blast crisis") of their illness were treated with a combination of agents known to be effective in both acute granulocytic and acute lymphocytic leukemia, (prednisone, mercaptopurine, and methotrexate; vincristine sulfate was added in five instances). Only one complete clinical remission was seen. One marrow remission in the face of increasing adenopathy was seen; there were two partial remissions. The toxicity was severe and included four drug-related deaths.
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