Antifungal diterpenes from the bark of Cryptomeria japonica D. Don

Abstract

Abstract Bioassay-guided isolation of compounds from n- hexane extracts of the bark of Cryptomeria japonica resulted in six abietane- and two pimarane-type diterpenoids, including a new compound, 12-methoxy-6α,11-dihydroxyabieta-8,11,13-triene. The structure of the new substance was established by spectral analyses and comparison with related compounds. The antifungal activities of these diterpenes were evaluated against the phytopathogenic fungi Alternaria alternata , Pyricularia oryzae , Rhizoctonia solani and Fusarium oxysporum . The diterpenes showed moderate antifungal activity against the fungi examined.