Microbiological Studies on Sodium 6-(2,6 Dimethoxybenzamido) Penicillanate Monohydrate (BRL 1241) in Vitro and in Patients

Abstract

A report in 1959 by Batchelor et al. on the isolation of 6-aminopenicillanic acid drew attention to the possibility of synthesizing new forms of penicillin by the introduction of side-chains. Derivatives prepared in this way may or may not possess antibacterial activity, but we were particularly impressed by the range and mode of action of one derivative, supplied to us in 1959 as BRL 1241 (" celbenin "). The compound-sodium 6- (2,6 dimethoxybenzamido)penicillanate monohydrate- may be represented by the following structural formula: OCH3 s /CH3