Concepedia

New Stable Reagents for the Nucleophilic Trifluoromethylation. 1. Trifluoromethylation of Carbonyl Compounds with <i>N</i>-Formylmorpholine Derivatives

Thierry Billard, Stefan Bruns, Bernard R. Langlois

Organic Letters · 2000 · 112 citations · 9 references

DOI

Abstract

A new stable equivalent of the trifluoromethyl anion has been synthesized from fluoroform. It reacts with nonenolizable carbonyl compounds such as the Ruppert's reagent.

References

9

Trifluoromethylations and related reactions in organic chemistry

M. A. MCCLINTON, Deborah A. McClinton · Tetrahedron · 1992 · 585 citations

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Organofluorine Compounds in Medicinal Chemistry and Biomedical Applications

General Pharmacology The Vascular System · 1994 · 363 citations

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Direct Preparation of Trifluoromethyl Ketones from Carboxylic Esters: Trifluoromethylation with (Trifluoromethyl)trimethylsilane

Jürgen Wiedemann, Thomas Heiner, Grzegorz Mlostoń et al. · Angewandte Chemie International Edition · 1998 · 146 citations

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Fluoroform: an Efficient Precursor for the Trifluoromethylation of Aldehydes

Benoı̂t Folléas, Ilan Marek, Jean‐F. Normant et al. · Tetrahedron · 2000 · 121 citations

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Fluoroform: an efficient precursor for the trifluoromethylation of aldehydes

Benoı̂t Folléas, Ilan Marek, Jean‐F. Normant et al. · Tetrahedron Letters · 1998 · 97 citations

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