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Preparation of Highly Functionalized Grignard Reagents by an Iodine-Magnesium Exchange Reaction and its Application in Solid-Phase Synthesis
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1998
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Materials ScienceSolid-phase SynthesisEngineeringGrignard ReagentsMagnesium-based CompositeCatalytic SynthesisOrganic ChemistryOrganometallic CatalysisCatalysisChemistrySynthesis MethodReagentAryl BromidesSynthetic ChemistryBiomolecular EngineeringIodine-magnesium Exchange ReactionWang Resin Behave
At -40°C aryl iodides that contain other functional groups can be selectively converted into Grignard reagents, which react with electrophiles such as benzaldehyde in the usual manner [Eq. (a)]. Aryl bromides and iodides that are immobilized as esters on a Wang resin behave analogously.