Use of 1,1,1,2-Tetrafluoroethane (R-134a)-Expanded Liquids as Solvent Media for Ecoefficient Particle Design with the DELOS Crystallization Process

Abstract

R-134a-expanded liquids have been used as solvent media for the straightforward crystallization of micron-sized crystalline powders using the depressurization of an expanded liquid organic solution (DELOS) procedure. The results, obtained with three different kinds of compoundsaspirin, hexamethylenetetramine, and solvent blue 35show that R-134-expanded liquids are suitable solvent media for material synthesis and processing at much lower working pressures (<1 MPa) than those required with compressed CO2 (>15 MPa) and even CO2-expanded solvents (≈10 MPa).