Integrin Regulation by Vascular Endothelial Growth Factor in Human Brain Microvascular Endothelial Cells

Abstract

The precise role of vascular endothelial growth factor (VEGF) in regulating integrins in brain microvascular endothelial cells is unknown. Here, we analyzed VEGF effects on integrin expression and activation in human brain microvascular endothelial cells (HBMECs). Using human cDNA arrays and ribonuclease (RNase) protection assays, we observed that VEGF up-regulated the mRNA expression of integrin in VEGF integrin integrin expression in of integrin expression the of and and VEGF in activation of integrins in of integrin the and in and and growth in VEGF expression and activation of in The precise role of vascular endothelial growth factor (VEGF) in regulating integrins in brain microvascular endothelial cells is unknown. Here, we analyzed VEGF effects on integrin expression and activation in human brain microvascular endothelial cells (HBMECs). Using human cDNA arrays and ribonuclease (RNase) protection assays, we observed that VEGF up-regulated the mRNA expression of integrin in VEGF integrin integrin expression in of integrin expression the of and and VEGF in activation of integrins in of integrin the and in and and growth in VEGF expression and activation of in endothelial growth factor (VEGF) vascular endothelial growth growth human brain microvascular endothelial human microvascular endothelial human endothelial growth protection vascular endothelial growth growth human brain microvascular endothelial human microvascular endothelial human endothelial growth protection vascular endothelial cells and role in and the VEGF VEGF and the expression of endothelial cells of the VEGF is of the expression activation of the the The integrin and and and activation of the the of the cells is the of integrins growth the of integrins effects on the of endothelial that integrins in VEGF integrins the the and in human endothelial cells 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