Carcinogenesis · 1987 · 14 citations · 0 references
MedicineOncologyToxicologyCarcinogenesisCutaneous OncologyNeoplasiaCarcinogenic MechanismsChemical CarcinogenesisEnvironmental CarcinogenesisMalignant NeoplasmsSkin TumorsTumor PromotionChemical Carcinogen ExposureChemical Carcinogenesis PromotionDevelopmental CarcinogenicityMechanisms Of CarcinogenicityMolecular CarcinogenesisSkin CarcinogenesisSkin Tumor PromotionTransplacental Carcinogenesis
Pregnant SHR mice were treated once with 7,12-dimethylbenz[a]anthracene (DMBA) on day 17-19 of gestation, and F1 and F2 descendants received multiple skin applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice a week for 24 weeks beginning at 12 weeks of age. Post-natal promoter treatment resulted in a high incidence of skin tumours in F1 and F2 mice (37.3 and 19.7%, respectively), whereas only 6.6% of control animals treated with TPA only developed skin tumours. DMBA was shown previously to be capable of initiating skin carcinogenesis transplacentally; however, our results on the second generation provide suggestive evidence of hereditary transmission of at least part of the initiating action of this carcinogen.