New News about an Old Drug: Investigations on the Polymorphism of Triamcinolone Acetonide

Abstract

Even a very old drug holds some surprises when its polymorphism is investigated in detail. The commercially available form of triamcinolone acetonide (modification I) is a hydrate that contains a small amount of water, which is responsible for its stability. The removal of water results in a transformation into the previously unknown modification II. This finding may have a large impact on the production of the dosage form. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601468_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.